Main Article Content
Racecodotril (RCT), (N-[2-[(acetylthio) methyl]-1- oxo- 3- phenyl propyl] -glycine phenylmethyl ester) is an enkephalinase inhibitor. A rapid, specific, and economic UV spectrophotometric two methods have been developed using a solvent composed of methanol to determine the RCT content in bulk and pharmaceutical dosage formulations. Method A is the absorbance maxima method, in which ?max is 231 nm, linearity was observed in the concentration range 10 to 100 ?g/mL for all the two methods, and exhibited good correlation coefficient for method A (r2 = 0.9991) and excellent mean recovery (98.22–102.77%). Method B is the area under curve (AUC), in which ?max 226 to 236 nm was selected for estimation of RCT and exhibited a good correlation coefficient for method B (r2 = 0.9953). The method was validated statistically and by recovery studies for linearity, precision, repeatability, and reproducibility. The obtained results reveal that the method can be employed for the routine analysis of RCT in bulks, as well as, in the commercial formulations.
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How to Cite
Ukirde RD, Sawant RL, Barkade GD. Development and Validation of simple UV Spectrophotometric Method for the Determination of Racecodotril both in Bulk and Marketed Dosage Formulations. ijpqa [Internet]. 2020 Sep. 25 [cited 2021 Aug. 1];11(03):334-7. Available from: http://ijpqa.openresearchjournals.com/index.php/ijpqa/article/view/492